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Support : Dialog Search Aids : EMBASE: Searching Drug Names

EMBASE® (Dialog Files 72, 73): Searching Drug Names

Indexing Descriptors (ALL) Descriptors (DRUG) Use of Drug Links Drug Brand Name

Indexing

All EMBASE items are indexed with thesaurus-controlled descriptors. The EMBASE thesaurus, EMTREE, includes medical terms, drug names, acronyms, MeSH® subject headings and spelling variations. Synonyms assigned by indexers are automatically translated to the corresponding EMTREE Preferred Term. Use the generic (preferred) term when searching an individual drug. For instance, items about "acetaminophen" or "4 acetamidophenol" (EMTREE synonyms) are indexed using the Preferred Term "paracetamol".

When an article mentions a drug for which there is not an EMTREE term, the drug group name is indexed and the term UNCLASSIFIED DRUG is added as a descriptor. This enables retrieval of articles on rare or new drugs by combining the drug class name and the term UNCLASSIFIED DRUG in a search statement, e.g., SELECT CALCIUM CHANNEL BLOCKING AGENT AND UNCLASSIFIED DRUG/DE. A new drug can also be searched by name in the entire Basic Index without a suffix, e.g., SELECT GRANISETRON OR BRL(W)43694.

Although descriptors are always EMTREE Preferred Terms (or candidate terms), a separate field is available for Drug Trade Names (/TN, TN=). This field is used to index laboratory and research codes as well as registered trade names. However, when a drug trade name is indexed, a corresponding EMTREE-controlled drug descriptor is always also indexed. In some cases this is the same term (for example when a generic name or chemical is not yet known for the drug), but if possible a generic name is used as the Preferred Term.

Example 1
Items that mention the anti-migraine drug Imigran have this term indexed as a trade name. However, the term sumatriptan succinate (Preferred Term of Imigran) is indexed as a drug descriptor.

Example 2
The beta blocker propranolol is known under a variety of trade names including Dociton and Inderal, which are indexed in the Drug Trade Name field in items which cite them. Other items on propranolol may contain other trade names, or even no trade names at all, if none are mentioned. But all are indexed using the descriptor propranolol.

EMTREE Preferred Terms can be searched specifically as descriptors, but searches need not be restricted to the descriptor field. Results are enhanced in both cases: when searched as descriptors, since all synonyms are translated to the Preferred Term and in unrestricted free-text searches, because such searches normally include the descriptor field.

It is essential that the Preferred Term is identified before the search is carried out. To find out whether a term is an EMTREE Preferred Term, use the online thesaurus or the printed EMTREE. To find the generic or preferred name of a drug, EXPAND the drug name within parentheses in the online thesaurus:

?EXPAND (UROCIT K)

Ref   Items Type  RT  Index-term
R1       14        1 *UROCIT K
R2      405   U   16  CITRATE POTASSIUM

As shown in the above display, CITRATE POTASSIUM is the preferred term for UROCIT K. Additional synonyms, descriptor codes, CAS Registry Numbers, and trade names for the drug can be obtained by EXPANDing the R number of the preferred term (R2):

?EXPAND R2

Ref  Items Type  RT  Index-term
R1     513       16 *CITRATE POTASSIUM
R2      16   B   63  CARBOXYLIC ACID SALT
R3    1311   B  189  HYDROXYACID
R4     777   B   22  TRICARBOXYLIC ACID
R5       0   S    1  CITRATE TRIPOTASSIUM
R6       0   S    1  DIPOTASSIUM CITRATE
R7       3   S    1  EFFERCITRATE
R8       0   S    1  MONOPOTASSIUM CITRATE
R9      20   S    1  POLYCITRA
R10     11   S    1  POLYCITRA K
R11      0   S    1  POTASSIUM CITRATE
R12     30   S    1  UROCIT
R13     29   S    1  UROCIT K
R14    513   S    1  RN=3609-96-9
R15    513   S    1  RN=7778-49-6
R16    513   S    1  RN=866-83-1
R17    513   S    1  RN=866-84-2 

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DESCRIPTORS (ALL) (/DE, /DF)

Descriptors are subject index terms and phrases assigned to each record to characterize the substantive content of the original document. All records in EMBASE are searchable using descriptors taken from the EMTREE thesaurus, published by Elsevier, the publisher of Excerpta Medica Abstract Journals. /DF is used to restrict retrieval to the single-word descriptor, e.g., S IBUPROFEN/DF.

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DESCRIPTORS (DRUG) (/DD, /DE)

For greater flexibility in searching, EMTREE terms applied to drugs are searchable with the /DD suffix or with the /DE suffix. Drug descriptors are searchable as single words, using proximity operators, or as complete phrases with the /DD suffix:

?SELECT HYDROCORTISONE(W)ACETATE/DD

?SELECT AMOXICILLIN PLUS CLAVULANIC ACID/DD

?TYPE S3/TI,DD

Clozapine and sudden death (multiple letters)
DRUG DESCRIPTORS:

*clozapine--adverse drug reaction--ae; *clozapine--drug 
concentration--cr; *clozapine--drug dose--do; 
*clozapine--drug therapy--;dt; amoxicillin plus 
clavulanic acid --drug therapy--dt; cytochrome P450 3A
--endogenous compound--ec; eosinophil cationic protein
--endogenous compound --ec; heparin--drug therapy--dt;
muscarinic M2 receptor--; endogenous compound--ec;
ozone; phenacetin o deethylase--endogenous 
compound--ec

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USE OF DRUG LINKS

Drug descriptors may be subdivided by means of topical subheadings or links. Links are used to restrict retrieval to precisely the aspect of the topic desired, such as DRUG TOXICITY. Links may be used only with allowable categories of EMTREE descriptors.

Links or subheadings included in the Descriptor field are searchable as single words (e.g., SELECT COMPLICATION/DE) or as complete phrases (e.g., SELECT DRUG INTERACTION/DE). Use the (L) operator to link the main heading and subheading. Subheadings are also searchable by two-letter abbreviations, as shown in the following example using AE for ADVERSE DRUG REACTION:

?SELECT THEOPHYLLINE(L)AE

?TYPE S6/TI,DE

Seizures and multifocal tachycardia caused by 
theophylline

DRUG DESCRIPTORS: *theophylline--drug toxicity--to; 
*theophylline--adverse drug reaction--ae 
salbutamol--drug therapy--dt; ipratropium bromide--drug 
therapy--dt MEDICAL DESCRIPTORS: *seizure--etiology--
et; *seizure--side effect--si; *tachycardia--;
etiology--et; *tachycardia--side effect--si 
asthma--drug therapy--dt; human; female; case 
report; aged; oral drug administration; 
inhalational drug administration; letter

Drug links focusing on "Routes of Drug Administration" have been added. These links are used whenever the appropriate concept is mentioned in the original document. The complete list of new drug links with abbreviations can be found at: http://support.dialog.com/searchaids/dialog/f72_drug_links.shtml

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DRUG BRAND NAME (/TN, TN=)

Drug brand or proprietary names mentioned in an article are indexed in the Drug Brand Name field. Brand names are searchable as single words, using proximity operators, or as complete phrases with the /TN suffix or TN= prefix.

?SELECT AUGMENTIN(W)XR/TN

?SELECT "ONE A DAY ACTIVE"/TN

?TYPE S3/TI,TN/1

A pharmacist's guide to OTC therapy

Brand Name/Manufacturer: maalox antacid 
barrier/Novartis; naturemade multimax/Pharmavite; 
one a day active/Bayer; one a day maximum/Bayer; 
pepcid ac ez chews/Johnson and Johnson; pepcid ac 
ez chews/Merck; pepto bismol/Procter and Gamble; 
tums for kids/Glaxo SmithKline; tums quickpak 
instant dissolve powder/Glaxo SmithKline

For comprehensive retrieval, SELECT alternative forms of entry:

?SELECT (NOVOSEVEN OR NOVO(W)SEVEN)/TN

?TYPE S4/TI,TN/5,34

  FEIBA(R) in treatment of acute bleeding episodes 
  in patients with haemophilia A and factor VIII 
  inhibitors: A retrospective survey in regional 
  haemophilia centre

Brand Name/Manufacturer: autoplex t/Baxter/United 
States; FEIBA/Baxter/Austria; novoseven/ Novo 
Nordisk/Denmark

Since 1988, trade names have been linked to manufacturer names, when provided by the author. Linked names are searchable using the (L) operator:

?SELECT FORTAZ(L)GLAXO?/TN

?TYPE S7/TI,TN

  Cephalosporins: A review

Brand Name/Manufacturer: ancef/Glaxo 
SmithKline/United States; ceclor/Lilly/United States; 
cedax/ Shinogi/United States; ceftin/Glaxo 
SmithKline/United States; cefzil/ Bristol Myers 
Squibb/United States; claforan/Hospira/United States; 
duricef /Bristol Myers Squibb/United States; 
fortaz/Glaxo SmithKline/ United States; 
keflex/advancis middle brook/United States; 
maxipime/Elan/ United States; 
maxipime/Squibb/United States; mefoxin/Merck and 
Co/United States; omnicef/Abbott/United States; 
rocephin/Hoffmann La Roche/United States; 
suprax/Lupin Laboratories/United States; 
vantin/Pfizer/United States; velosef/Bristol Myers 
Squibb/United States; zinacef/Glaxo 
SmithKline/United States 

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Related Document:

EMBASE (Files 72, 73) Drug Links

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