Support : Publications : Chronolog Archives : September 2001

Recent and Relevant Congress Coverage in Prous Science Daily Essentials

Coverage of recent and ongoing congresses and symposia is a unique feature of the Prous Science Daily Essentials drug news files on Dialog (Files 458, 459) and DataStar (PRED, PREC, PRES). This information is easily retrieved by searching on Publication Type (PT=Congress) in DataStar or Document Type (DT=Congress) in Dialog.

With the Prous Science Daily Essentials, it is also easy to retrieve information on new pharmaceutical compounds that have been publicly described for the first time. This is done by searching on the Status (ST) field in Files 458, 459 or the Scope (SC) field in PRED/PREC/PRES. A search for records with Status/Scope=New Compound and Publication Type/Document Type=Congress is a powerful tool for obtaining information on new drugs that have not previously appeared in the biomedical literature. Refer to the Dialog Bluesheet at http://library.dialog.com/bluesheets and the DataStar Datasheet at http://library.dialog.com/datasheets for search tips.

File 458 and PREC contain records published in the most recent four weeks. For example, the more than 130 citations to congresses and symposia found in the Prous Science Daily Essentials current files during the first week of July 2001 were to meetings in such diverse biomedical arenas as chemotherapy, headaches, diabetes, neurology, hypertension, rheumatism, heart failure, transplantation and gene therapy (see Table 1 below). The majority of these 130+ records provides new results from experimental or clinical trials for previously known compounds; however, adding the New Compound constraint to the search criteria retrieves a core set of 25-30 records — many with chemical structure images — describing heretofore unknown compounds, some of which are postulated to have a novel mechanism of action (see Table 2 below).

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* 22nd Intl Cong Chemother 
* 10th Cong Intl Headache Soc
* 61st Sci Sess Amer Diabetes Assoc 
* ENDO 2001 - 83rd Annu Meet Endocrine Soc
* 17th World Cong Neurol
* 11th Eur Meet Hypertension
* EULAR 2001
* Heart Failure 2001 Meet
* 1st Joint Meet Intl Bone Miner Soc Eur Calcif Tissue Soc
* 96th Annu Meet Amer Urol Assoc
* 4th Annu Meet Amer Soc Gene Ther

Table 2. Partial list of type of new compounds described in Prous Science Daily Essentials current archive (F458/PREC) - week of July 2-6, 2001

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* Small-molecule GSK-3 inhibitors
* Novel AGE production inhibitors
* PTP1B inhibitors
* Glycogen phosphorylase inhibitors
* Cyclohexapeptide somatostatin analogues
* LMW activators of hIRTK
* Anti-PPARgamma compounds
* Mitochondrial metabolism modulators
* glucokinase activators
* nonpeptide glucagon receptor antagonists
* ATP-sensitive potassium channel openers
* VPAC2 receptor agonists
* MC4 receptor agonists
* Nonsteroidal selective estrogen receptor modulators
* Alphavbeta3 integrin antagonists
* Dual FPP synthase and IPP isomerase inhibitors
* CACC-1 inhibitors
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The Prous Science Daily Essentials files, which are updated daily, excel at providing this sort of "mission-critical" knowledge to the pharmaceutical industry in a timely fashion and with search options that facilitate the retrieval of specific information types. Options for the Status/ Scope search field are New Compound, Licensing Opportunities, Line Extensions, New Approvals, and New Launches; Document Type/ Publication Type search criteria are Congress, Patent, Current Literature, Company Communication, and Quarterly/Semi-Annual/ Annual Reports. It is also possible to search for records by broad (e.g., Cardiovascular Drugs) or narrow (e.g., Antihypertensive Drugs) therapeutic categories.

And, every drug cited in the Prous Science Daily Essentials current files on Dialog and DataStar has an associated identifier (Prous Science Entry Number) that can be used to search in the archival Daily Essentials files (F45/PRES) or other Prous Science files (Drugs of the Future, F453/PRFU; Drug Data Report, F452/PRDR) for additional information, such as a product monograph and scheme of synthesis (F453/PRFU) or exhaustive patent and literature references (F452/PRDR).

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