Support : Publications : Chronolog Archives : September 2001

Adis Clinical Trials Insight on DataStar™: the new, improved LMS Drug Alerts

Since 1983, Adis LMS Drug Alerts has been a valued source of highly structured evaluations of key papers from the international medical and biomedical journals on drugs, drug therapy, adverse drug reactions and pharmacoeconomics.

Now Adis is relaunching LMS Drug Alerts with a new title: Clinical Trials Insight (CTI) (label: ACTI) and a number of major improvements. These are:

• Full-text structured assessments appear in all records (only 15% of the records in LMS Drug Alerts have assessments)
• All clinical and volunteer studies are covered

• Search clinical relevance ratings
• Search evaluation scores
• Search phase of study
• Search type of study design
• Search study control

Unique in the field, Clinical Trials Insight puts you on the inside track with the latest clinical trial results with expert evaluation from informed Adis scientists. A CTI search will provide you with invaluable information in your therapeutic area on trial results, clinical significance, product applications and cost analysis — facts that would normally take extensive research to compile and analyze. From efficacy, tolerability and pharmacoeconomic outcomes to trial design score, clinical relevance ranking and key study messages, CTI provides the uniform measures needed to assess the reliability and applicability of today's clinical trial results. Acknowledged experts in clinical trial monitoring, Adis scientists review the best evidence from more than 1,700 peer-reviewed biomedical publications — providing the pertinent information from timely and groundbreaking studies.

If you are engaged in

• Product positioning
• Adverse event reporting
• Brand protection
• Clinical development
• Strategic planning
• Product assessment

then Adis Clinical Trials Insight can help you. Whether you are seeking clinical data to support an advantage for your drug or comparing studies to refute a competitor's claim, CTI ensures that critical information is only a keystroke away.

Let Clinical Trials Insight help you

• Learn how a new drug class performs in relation to existing agents
• Identify key specialists or researchers working with a specific drug
• Locate follow-up data and analysis on a specific trial or series of trials
• Pinpoint new markets for your drug in the treatment of related disorders
• Find evidence of a drug's effectiveness in a range of patient populations
• Assess key cost-effectiveness data for a drug in various work markets
• Track all significant safety reports for a drug.

Accompanying the improved content of CTI are a number of new improved search features that will help you pinpoint the information you need.

Expert Performance Rating. Adis evaluation of each study includes analysis of the positive and negative features of the study design and unique Adis ratings of the trial design - all combined to provide you with an essential uniform measure of study reliability, clinical relevance and marketing implications. This information is located in the Evaluation (EV) paragraph on DataStar.

Clinical relevance ratings can be searched using the following quick codes:

CL=A (Study provides new evidence of clinical relevance)

CL=B (Study provides supporting evidence to existing data)

CL=C (Study adds no new or important information)

Evaluation scores are based on the adequacy of the data provided by the report and is a cumulation of the individual scores awarded to elements of the study design and conduct. The Limit command allows you to include only documents that fall within a particular evaluation score. Scores are categorized as:

Adis Comments provide insight on the development phase of a research drug,
commercial drug information and strengths or limitations of the study design. You may also be directed to meeting abstracts and accompanying editorials relevant to the study. This information is searchable free-text.

Details of the study are presented within the main text of the document (paragraph TX on DataStar). The TX paragraph is searchable free text; the following quick codes have also been added to make it easier to pinpoint certain aspects of the study.

Other search features in Clinical Trials Insight include searching by drug class, route of administration, patient criteria or author. Refer to the DataStar datasheet at http://library.dialog.com/datasheets or the DataStar Database of Databases (file label: BASE; search for BASE-ACTI) for a detailed search guide to CTI.

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