The Record: File 452 (cont'd)
The last feature that Sharon might find useful is the "References" section. For example, for this drug there is an extensive bibliography.
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References: Wood, J. et al., "Pharmacological profile of a potent and orally active inhibitor of VEGF receptor tyrosine kinases", Proc Am Assoc Cancer Res (AACR) 1998,39 Abst 655 Drevs, J. et al., "Phase I dose escalation, pharmacokinetic (pk) study of a novel vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK)", Eur J Cancer 1999,35(Suppl. 4) Abst 1137 Manley, P.W. et al., "Rationalization of the selective inhibition of VEGF-tyrosine kinase by the angiogenesis inhibitor, PTK787/ZK222584 (1) on the basis of shape complementarity to hydrophobic domains within the ATP-binding site", AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 16-19, Washington DC) 1999, Abst 256 Xu, L. et al., "Therapy of VEGF-dependent human ovarian carcinoma by oral administration of CGP 79787/ZK222584, an inhibitor of the VEGF receptor tyrosine kinase", Proc Am Assoc Cancer Res (AACR) 1999,40 Abst 3020 Ozaki, H. et al., "Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization", Am J Pathol 2000,156(2): 697 Wood, J.M. et al., "Vascular endothelial growth factor receptor tyrosine kinase inhibition, an effective therapy against human prostatic carcinomas in nude mice", Proc Am Assoc Cancer Res (AACR) 2000,41 Abst 299 Wood, J.M. et al., "Magnetic resonance imaging of tumor permeability: A non-invasive marker for the efficacy of a VEGF-receptor tyrosine kinase inhibitor", Proc Am Assoc Cancer Res (AACR) 2000,41 Abst 2460 Soorzano, C.C. et al., "Blockade of VEGF-R signaling inhibits growth and metastasis of human pancreatic cancer", Proc Am Assoc Cancer Res (AACR) 2000,41 Abst 3620 Wood, J.M. et al., "PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration", Cancer Res 2000,60(8): 2178 Bold, G. Altmann, K.-H. Frei, J. et al., "New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis", J Med Chem 2000,43(12): 2310 Manley, P.W. Bold, G. Furet, P. Hofmann, F. Wood, J.M., "SAR studies on the angiogenesis inhibitor, PTK787/ZK222584 (1)", 27th Natl Med Chem Symp (June 13-17, Kansas City) 2000, Abst A-20 Bold, G. Altmann, K.-H. Frei, J. et al., "New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis. (Erratum)", J Med Chem 2000,43(16): 3200
Take a look at a couple of bibliographic entries before going to the next page to review Prous Science Drugs of the Future (File 453).