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The Record: File 452 (cont'd)

The last feature that Sharon might find useful is the "References" section. For example, for this drug there is an extensive bibliography.
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References: 
Wood, J. et al., "Pharmacological profile of a potent and orally active
inhibitor of VEGF receptor tyrosine kinases", Proc Am Assoc Cancer Res
(AACR) 1998,39 Abst 655

Drevs, J. et al., "Phase I dose escalation, pharmacokinetic (pk) study
of a novel vascular endothelial growth factor (VEGF) receptor inhibitor,
PTK787/ZK 222584 (PTK/ZK)", Eur J Cancer 1999,35(Suppl. 4) Abst 1137

Manley, P.W. et al., "Rationalization of the selective inhibition of
VEGF-tyrosine kinase by the angiogenesis inhibitor, PTK787/ZK222584 (1) 
on the basis of shape complementarity to hydrophobic domains within the
ATP-binding site", AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov
16-19, Washington DC) 1999, Abst 256

Xu, L. et al., "Therapy of VEGF-dependent human ovarian carcinoma by
oral administration of CGP 79787/ZK222584, an inhibitor of the VEGF
receptor tyrosine kinase", Proc Am Assoc Cancer Res (AACR) 1999,40 Abst
3020

Ozaki, H. et al., "Blockade of vascular endothelial cell growth factor
receptor signaling is sufficient to completely prevent retinal
neovascularization", Am J Pathol 2000,156(2): 697

Wood, J.M. et al., "Vascular endothelial growth factor receptor
tyrosine kinase inhibition, an effective therapy against human prostatic
carcinomas in nude mice", Proc Am Assoc Cancer Res (AACR) 2000,41 Abst 
299

Wood, J.M. et al., "Magnetic resonance imaging of tumor permeability: A
non-invasive marker for the efficacy of a VEGF-receptor tyrosine kinase
inhibitor", Proc Am Assoc Cancer Res (AACR) 2000,41 Abst 2460

Soorzano, C.C. et al., "Blockade of VEGF-R signaling inhibits growth
and metastasis of human pancreatic cancer", Proc Am Assoc Cancer Res 
(AACR) 2000,41 Abst 3620

Wood, J.M. et al., "PTK787/ZK 222584, a novel and potent inhibitor of
vascular endothelial growth factor receptor tyrosine kinases, impairs
vascular  endothelial growth factor-induced responses and tumor growth
after oral administration", Cancer Res 2000,60(8): 2178

Bold, G. Altmann, K.-H. Frei, J. et al., "New anilinophthalazines as
potent and orally well absorbed inhibitors  of the VEGF receptor tyrosine
kinases useful as antagonists of tumor-driven angiogenesis", J Med Chem
2000,43(12): 2310

Manley, P.W. Bold, G. Furet, P. Hofmann, F. Wood, J.M., "SAR studies on
the angiogenesis inhibitor, PTK787/ZK222584 (1)", 27th Natl Med Chem Symp
(June 13-17, Kansas City) 2000, Abst A-20

Bold, G. Altmann, K.-H. Frei, J. et al., "New anilinophthalazines as
potent and orally well absorbed inhibitors  of the VEGF receptor tyrosine
kinases useful as antagonists of tumor-driven angiogenesis. (Erratum)", J
Med Chem 2000,43(16): 3200
[the remaining references have been omitted from this display]

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Tip 5-8

Take a look at a couple of bibliographic entries before going to the next page to review Prous Science Drugs of the Future (File 453).


5-6

Authoritative Answers Enriched by ProQuest

Learn More #6:

Bibliographic citations in File 452 include journals, books or congresses and other meetings.

Each citation has the authors' names, title, journal, book or meeting name, year, volume number and page numbers, as applicable to each reference type.

Like Adis R&D Insight, Drug Data Report provides a good start-up bibliography, growing in extent as a drug progresses through the pipeline.

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Learn More #7:

File segment (FS=) appears only in some records.

Contents can be "actively investigated" for compounds considered to be in active development or "New Molecular Entity (NME)" for compounds recently described for the first time at a congress, in current literature or in a company communication and identified with a code number, generic name or chemical name. The latter compounds have not yet been published in the journal Prous Science Drug Data Report and the entry in the database anticipates the print edition.

This information is preliminary and may be revised or updated until the time of the compound's publication in print. The NME label then disappears.

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Search Tip 5-8:

To search a file segment, use EXPAND and the FS= prefix.

Example:
Expand FS=
Ref Items Index-term
E1 7 CO=ZYMOGENETICS
E2 17 CO=3M
E3 0 FS=
E4 1453 FS=ACTIVELY INVESTIGATED E5 94 FS=NEW MOLECULAR ENTITY
E6 12 LI=ABBOTT
E7 1 LI=ABBOTT TOYAMA
E8 1 LI=ABELLO
. . .