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Find Peer-reviewed Studies in Biomedical Literature for a Specific Drug and Indication?
TOPIC: In this example, using two biomedical databases MEDLINE® (File 154) and EMBASE® (File 72), you want to find recent human research studies in English for the drug Baclofen, a drug used for spasticity and pain. MEDLINE® is a major source of biomedical literature. EMBASE® also contains biomedical information with a focus on drug literature. Both databases have their own thesaurus to help in locating search terms.
COMMAND SUMMARY
BEGIN 154,72
SELECT BACLOFEN/TI,DE
SELECT S1 AND SPASTICITY/TI,DE
SELECT S2/HUMAN,ENG,2005
SELECT S3 NOT CEREBRAL()PALSY
RD
TYPE S5/6/1-2 FROM EACH
TYPE S5/9/1
HOW TO...
1. BEGIN 154 and 72, databases containing biomedical and drug literature.
2. SELECT the drug name and disease limited to the title (/TI) and descriptors (/DE).
3. Limit the set to human subjects (/human) and English language records (/eng) from 2005 (/2005).
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?b 154,72
SYSTEM:OS - DIALOG OneSearch
File 154:MEDLINE(R) 1990-2006/Aug 22
(c) format only 2006 Dialog
File 72:EMBASE 1993-2006/Aug 23
(c) 2006 Elsevier B.V.
Set Items Description
--- ----- -----------
?SELECT BACLOFEN/TI,DE
S1 7852 BACLOFEN/TI,DE
?SELECT S1 AND SPASTICITY/TI,DE
7852 S1
6485 SPASTICITY/TI,DE
S2 1191 S1 AND SPASTICITY/TI,DE
?SELECT S2/HUMAN,ENG,2005
995 S2/HUMAN,ENG
1195306 PY=2005
S3 104 S2/HUMAN,ENG,2005
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4. Eliminate records related to “cerebral palsy.”
5. Remove duplicate records (RD) when searching more than one database. |
?SELECT S3 NOT CEREBRAL()PALSY
104 S3
266605 CEREBRAL
30646 PALSY
12418 CEREBRAL(W)PALSY
S4 79 S3 NOT CEREBRAL()PALSY
?RD
S5 68 RD (unique items) |
6. TYPE S5 in Format 6 and use the FROM EACH command to see the first two records from each database. |
?T S5/6/1-2 FROM EACH
5/6/1 (Item 1 from file: 154)
19948352 PMID: 15781838
Incidence of seizures in patients with multiple sclerosis treated with intrathecal baclofen .
Mar 22 2005
5/6/2 (Item 2 from file: 154)
19880389 PMID: 16134742
Prolonged anti-spasticity effects of bolus intrathecal baclofen.
Jul 2005
5/6/16 (Item 1 from file: 72)
13863570 EMBASE No: 2005421660
Skeletal muscle relaxants and associated medications for nonspecific acute back pain
2005
5/6/17 (Item 2 from file: 72)
13722369 EMBASE No: 2005304193
Current perspectives in the pathogenesis and treatment of multiple sclerosis
2005 |
7. TYPE desired record(s) in S5 using Fomat 9 to see the complete record. |
?T S5/9/2
5/9/2 (Item 2 from file: 154)
DIALOG(R)File 154:MEDLINE(R)
(c) format only 2006 Dialog. All rts. reserv.
19880389 PMID: 16134742
Prolonged anti- spasticity effects of bolus intrathecal baclofen.
Baguley I J; Bailey K M; Slewa-Younan S
Brain Injury Rehabilitation Service, Westmead Hospital, Wentworthville, NSW, Australia. ianb@biru.wsahs.nsw.gov.au
Brain injury - BI (England) Jul 2005 , 19 (7) p545-8, ISSN 0269-9052--Print Journal Code: 8710358
Publishing Model Print
Document type: Case Reports; Journal Article
Languages: ENGLISH
Main Citation Owner: NLM
Record type: MEDLINE; Completed
Subfile: INDEX MEDICUS
Anecdotal patient reports have suggested prolonged benefit from the initial bolus dose of intrathecal baclofen (bolus ITB) that have not been evident on the Modified Ashworth Scale (MAS). This case study assessed this effect utilizing surface electromyography (SEMG) as an adjunct to clinical
observations. Overall, SEMG recordings were consistent with MAS findings. However, SEMG also revealed a marked and persisting reduction in abnormal muscle activity for 96 hours post-bolus ITB, well beyond the pharmacological washout period of baclofen in the CSF.
Tags: Male
Descriptors: *Baclofen --therapeutic use--TU; *Muscle Relaxants, Central--therapeutic use--TU; *Muscle Spasticity --drug therapy--DT; Adult; Brain Injuries--complications--CO; Electromyography; Humans; Injections, Spinal;
Muscle Spasticity--etiology--ET
CAS Registry No.: 0 (Muscle Relaxants, Central); 1134-47-0 (Baclofen)
Record Date Created: 20050901
Record Date Completed: 20060209
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