2. SELECT keywords to include any status a drug might be in.

3. SELECT the therapeutic class code for immuno-suppressive agents (L4A) and narrow the search to the most recent years.

Note that the therapeutic class code contains truncation to retrieve all narrower classes.

?B 445

File 445:IMS R&D Focus 1991-2006/Aug W2
       (c) 2006 IMS Health & Affiliates

      Set  Items  Description
      ---  -----  -----------
?SELECT PHASE OR CLINICALS OR IND OR PRE()REGISTRATION OR NDA
           37829  PHASE
             438  CLINICALS
            4004  IND
            4027  PRE
            3873  REGISTRATION
            3335  PRE(W)REGISTRATION
            3251  NDA
      S1   40871  PHASE OR CLINICALS OR IND OR PRE()REGISTRATION OR NDA

?SELECT TC=L4A?
      S2    3530  TC=L4A?

?SELECT S2 AND PY=2004:2006
            3530  S2
           29752  PY=2004 : PY=2006
      S3    1428  S2 AND PY=2004:2006

4. RANK the company name (CO). Rank lets you extract the companies that are working most in this therapeutic class and ranks them with the company with the highest number of drugs listed first.

From the displayed list of companies, type the numbers of the ones that you want to track, in this example the top 5.

Exit the rank menu to continue searching.

Type YES if you have saved all terms of interest.

?RANK CO
Started processing RANK
Processing    500 of   1428 records
Processing   1000 of   1428 records
Completed Ranking 1428 records
DIALOG RANK Results
--------------------
RANK: S3/1-1428   Field: CO=  File(s): 445
(Rank fields found in 1428 records -- 441 unique terms) Page 1 of 56
RANK No.  Items  Term
--------  -----  ----
    1       40   NOVARTIS
    2       32   AMGEN
    3       31   SERONO
    4       26   BIOGEN IDEC
    5       24   CELGENE
    6       23   ROCHE
    7       22   ASTELLAS
    8       22   WYETH
P =  next page      Pn = Jump to page n
P- = previous page  M =  More Options     Exit = Leave RANK
To view records from RANK, enter VIEW followed by RANK number,
format, and item(s) to display, e.g., VIEW 2/9/ALL.
Enter desired option(s) or enter RANK number(s) to save terms.
?1-5

RANK numbers saved: 1-5
DIALOG RANK Results
--------------------
RANK: S3/1-1428   Field: CO=  File(s): 445
(Rank fields found in 1428 records -- 441 unique terms) Page 1 of 56
RANK No.  Items  Term
--------  -----  ----
    1       40   NOVARTIS
    2       32   AMGEN
    3       31   SERONO
    4       26   BIOGEN IDEC
    5       24   CELGENE
    6       23   ROCHE
    7       22   ASTELLAS
    8       22   WYETH
P =  next page      Pn = Jump to page n
P- = previous page  M =  More Options     Exit = Leave RANK
To view records from RANK, enter VIEW followed by RANK number,
format, and item(s) to display, e.g., VIEW 2/9/ALL.
Enter desired option(s) or enter RANK number(s) to save terms.
?exit

RANK results will be erased; have you saved all the terms of interest?
(YES/NO)
?y

5. Execute (EXS) the SearchSave you created from the Rank menu with the top 5 companies.

6. Combine sets of company names, keywords, and therapeutic class limited by publication year.

Temp SearchSave "TD494" stored
Creating temporary SearchSave ... TD494
Enter EXS to execute the SearchSave

?EXS
Executing TD494
      S4    1584  CO="NOVARTIS"
      S5     583  CO="AMGEN"
      S6     272  CO="SERONO"
      S7     161  CO="BIOGEN IDEC"
      S8     175  CO="CELGENE"
      S9    2758  S4:S8

?S S1 AND S3 AND S9
           40871  S1
            1428  S3
            2758  S9
     S10     104  S1 AND S3 AND S9    

7. TYPE out a few records to check the relevance of your search before setting up the Alert.

Note the drug name, originator, therapeutic class code and development status.

?T S10/3/1-2
 
  10/3/1  
DIALOG(R)File 445:IMS R&D Focus
(c) 2006 IMS Health & Affiliates. All rts. reserv.
 
02025059
R&D Focus - February 06, 2006 (20060206)
 
COMPANY INFORMATION:
  Originator:               Celgene; (USA); NA; NA; NA
 
DRUG INFORMATION:
  Laboratory Code:          CC 10015
  Pharmacological Action:   TNF modulator; immunosuppressant
  Therapeutic Class Code:   L4A (Immunosuppressive Agents)
  Clinical Indications:     inflammation
  Molecular Code:           7189120000
 
CURRENT DEVELOPMENT STATUS:
  Highest Phase:            Preclinical (20)
 
  10/3/2  
DIALOG(R)File 445:IMS R&D Focus
(c) 2006 IMS Health & Affiliates. All rts. reserv.
 
02025058
R&D Focus - February 06, 2006 (20060206)
 
COMPANY INFORMATION:
  Originator:               Celgene; (USA); NA; NA; NA
 
DRUG INFORMATION:
  Laboratory Code:          CC 11006
  Pharmacological Action:   TNF modulator; immunosuppressant
  Therapeutic Class Code:   N7X (All Other CNS Drugs);D3A (Wound
                            Agents);L4A (Immunosuppressive Agents)
  Clinical Indications:     inflammation; pulmonary fibrosis; scleroderma; amyotrophic lateral sclerosis
  Molecular Code:           7189110000
 
CURRENT DEVELOPMENT STATUS:

8. Type SAVE ALERT to begin setting up the Alert; then follow the Alert menu.

Select when you want the Alert to run--when the file is updated or on a schedule of your choosing.

Remove duplicates.

Review your Alert settings and SAVE them.

Enter a name for the Alert.

Enter a PRINT command. In this example, the Alerts will be sent to the e-mail address at the end of the Print statement.

SAVE the Alert.

?SAVE ALERT
Do you want the Alert run based on a file's Alert Update schedul
or on a Custom schedule you set up?   U=Update  C=Custom  Q=Quit  H=Help

?U
If a file has multiple update frequencies, do you want to accept
the default or choose file by file?  D=Default  C=Choose 
Q=Quit  H=Help

?D
Do you want duplicates removed automatically?    Y=Yes  N=No  H=Help

?Y
Do you want notification even if no documents are found? 
Y=Yes  N=No

?N

Your alert currently has these settings:
1. Databases:    445
2. Frequency:    When database is updated
                 445(W)
3. Run at:       When database is updated
4. Dedupe:       Y
5. Notify:       ONLY when new documents are found (Notify=OFF)
To make a change, enter a line number.
To save the Alert, enter S for Save.               Q=Quit  H=Help
?S

Enter 1 to 30 characters for a name.               Q=Quit  H=Help
?COMPANIES

Enter a PRINT statement for your Alert.           Q=Quit  H=Help
?PR S10/9/ALL ADDR BAJABEV

Enter the next PRINT command or enter S to SAVE.      
Q=Quit  H=Help
?S