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Find Reported Side Effects of a Drug and Its Interactions with Other Drugs?
TOPIC: In this example, using ToxFile® (File 156), you want to find reported side effects from the drug Paxil (paroxetine), used to treat anxiety and depression. ToxFile covers the toxicological, pharmacological, biochemical and physiological effects of drugs. Similar to MEDLINE®, ToxFile lets you search headings linked to subheadings (e.g., side effects (SI)) using the (L) connector. Note: if you need to find the generic name for a drug, use Embase®.
In this example you want to find adverse effects of Paxil and its interaction with other drugs.
COMMAND SUMMARY
BEGIN 156
SELECT PAXIL OR PAROXETINE
SELECT S1(L) (AE or TO or PO or SI)
SELECT S2/2005
TYPE S3/6/ALL
Click Links > Display > Type Full Record
SELECT PAROXETINE/DE AND DRUG()INTERACT?/TI,DE,ID
SELECT S4/2005
TYPE S5/6/all
Click Links > Display > Type Full Record
Check records > select format
HOW TO...
1. BEGIN 156, a database containing effects of drugs and chemicals.
2. SELECT the drug name and synonyms.
3. Use the (L) connector to link to subheadings for adverse effects (AE), toxicity (TO), poisoning (PO) and side effects (SI).
4. Limit the search to the current year. |
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5. TYPE titles using Format 6.
6. Use Links to display the full record. which includes title, author, journal data and abstract.
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The full record contains title, author, journal data and abstract.
Note the headings in the descriptor field linked to sub-headings.
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7. To find drug interactions, use the generic drug name limited to the descriptors and “drug interactions” restricted to the title, descriptors and identifiers.
8. Narrow the search to the current year.
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9. TYPE all records in Format 8 to see titles and descriptors.
Note that drug interactions is a heading listed in the descriptor field. |
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RELATED HOW DO I...? SOLUTIONS
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