 |
Find Reported Adverse Effects of a Particular Drug?
TOPIC: In this example, using three biomedical databases MEDLINE® (File 154), Embase® (File 72) and Embase® Alert (File 172), you want to find adverse effects reported for the anti-anxiety drug Paxil, especially as it relates to hair loss.
MEDLINE® is a major source of biomedical literature and Embase® contains biomedical information with a focus on drug literature. Both files provide excellent indexing — thesauri — which guide you to the right terms with a simple EXPAND command. Because MEDLINE and Embase use different indexing (NLM Medical Subject Headings MeSH® and Emtree respectively) it is best to EXPAND, browse terms and SELECT terms FROM EACH file. You can select specific adverse effects indexing from the EXPANDs or select the drug name and combine it with the two-letter codes for the adverse effects you want. The (L) connector links the heading (paroxetine) to subheadings (adverse effects) found in the descriptor field.
It is important to pick up new documents quickly. Embase Alert and "In Process" records in MEDLINE are not indexed, so in order to do a comprehensive search, a free-text version of the indexed strategy must also be part of a comprehensive search strategy.
COMMAND SUMMARY
BEGIN 154,72,172
EXPAND PAROXETINE FROM 154
SELECT E3 (L) (AE OR TO OR CT OR PO)FROM 154
EXPAND PAROXETINE FROM 72
SELECT E3 (L) (AE OR TO OR IT) FROM 72
SELECT PAROXETINE (10N)(ADVERSE OR SIDE)(3N)(REACTION OR EFFECT? ?) OR
PAROXETINE (10N)(CONTRAINDICATION? OR POISON? OR TOXIC?)
SELECT S1:S3
SELECT S4 AND (HAIR()LOSS OR ALOPECIA)
RD
Click S6 > Tasks > Picklist
TYPE S6/6/1-2 FROM EACH
TYPE S6/9/2
HOW TO...
1. After BEGINning in MEDLINE and EMBASE, EXPAND using the generic name for Paxil FROM MEDLINE (File 154).
|
|
2. SELECT the appropriate E number (E3) and use the (L) operator to link headings with the subheadings for adverse effects (AE), toxicity(TO), contraindications (CT) and poisoning (PO).
3. EXPAND the drug name FROM Embase and SELECT the appropriate E-reference number FROM Embase. SELECT the appropriate E number (E3) and use the (L) operator to link headings with the subheadings for adverse drug reaction (AE), toxicity (TO) and drug interactions (IT).
|
|
4. Enter free-text terms related to adverse effects from the generic name for Paxil.
5. OR the sets together using a colon for the range of S1-S3.
6. Remove duplicate records (RD) when using more than one database.
7. To view titles, in the Set Links pane, click S6 > Tasks > Picklist. |
|
8. Check record(s) you want to view in more detail, select Output Format and click Output.
|
|
9. The full records display. |
|
10. Use the TYPE command to view a sampling of records FROM EACH database. |
|
11. Use record links to display the full records of choice, or TYPE the desired records in Format 9. |
|
RELATED HOW DO I...? SOLUTIONS
NEED HELP?
Contact the Dialog Knowledge Center
Within North America 1 800 3 DIALOG (334 2564)
Outside North America 00 800 33 DIALOG (33 34 2564)
Web Form www.dialog.com/contacts/webform
|
You are viewing the
Click below to view the
|
