1. BEGIN File 266 to search Federal Research in Progress.

2. SELECT search terms using proximity connectors and narrow to the Title or the Descriptor (/TI,DE) fields.

The connector (N) specifies the words can be in either order. Placing a number before the N indicates how many words can appear between the connected terms.

The question mark truncation symbol allows for variant word endings.

3. SELECT Set 1 (S1) AND the current fiscal year (FY=).

?b 266      

File 266:FEDRIP 2008/Apr
       Comp & dist by NTIS, Intl Copyright All Rights Res

      Set  Items  Description
      ---  -----  -----------
?s gene(5n)sequenc?/ti,de
           21014  GENE/TI,DE
            4523  SEQUENC?/TI,DE
      S1     878  GENE(5N)SEQUENC?/TI,DE

?s s1 and fy=2008
             878  S1
           27387  FY=2008
      S2      55  S1 AND FY=2008

4. TYPE a few records in Format 8 to browse titles and indexing. This helps you to see if you’re on the right track. The descriptor terms give insight on ways to tighten or hone the search.

Notice that the contributing government agency code appears above the title. The field to search the agency is File Segment (FS=).

Note: Some records have been omitted from this display.

To select the appropriate record number, look at the range of records in the TYPE command (e.g., 2/8/2).

?t s2/8/1-5

2/8/1
DIALOG(R)File 266: FEDRIP
Comp & dist by NTIS, Intl Copyright All Rights Res.
All rights reserved.

00655026
Identifying No.: 5R01MH066877-07   Agency Code: CRISP
Searching for ADHD Susceptibility Genes

Descriptors: attention deficit disorder; pathologic process;
gene interaction; genotype; nucleic acid sequence;
longitudinal human study; phenotype ; family genetics; human
data; gene environment interaction; clinical research;
disease /disorder etiology; genetic susceptibility; single
nucleotide polymorphism

2/8/2
DIALOG(R)File 266: FEDRIP
Comp & dist by NTIS, Intl Copyright All Rights Res.
All rights reserved.

00650098
Identifying No.: 5R21HL082670-02   Agency Code: CRISP
SHP-2 Inhibitors as Potential Therapeutic Agents for JMML
and Noonan Syndrome

Descriptors: hematopoiesis; blood /lymphatic pharmacology;
cell differentiation; chemical information system; chemical
structure function; phosphatase inhibitor; genetic disorder;
gene mutation; computer assisted sequence analysis;
myelogenous leukemia; protein structure; cell line; protein
tyrosine phosphatase; cell proliferation; protein binding;
protein interaction; drug discovery /isolation

. . . .

5. Use RANK to get a quick snapshot of the sponsoring agencies (SP) in these 55 records. CONT provides a continuous display.

Follow the RANK menu prompts. Pressing <ENTER> brings up the highest ranked 50 sponsoring agencies in the set.

Note: If your focus is on universities, institutions and medical facilities performing the research, RANK CS CONT. The CS field is the Corporate Source.

Enter EXIT to leave RANK and confirm with Yes (Y).

?rank sp cont

Started processing RANK
Completed Ranking 55 records

Press ENTER to view the TOP 50 terms
   or enter a number N to view the top N terms
   or >N to view terms with more than N items
   or enter ALL to view all terms

Enter title for continuous output or press ENTER for 
current title option
?sponsoring agencies fedrip gene sequence

Adding title to results...

SPONSORING AGENCIES FEDRIP GENE SEQUENCE
----------------------------------------

RANK: S2/1-55   Field: SP=  File(s): 266
(Rank fields found in 55 records -- 15 unique terms)

RANK No.  Items  Term
--------  -----  ----
    1       16   NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS D
    2       14   NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
    3        6   NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
    4        3   NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE A
    5        3   NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCI
    6        2   NATIONAL CANCER INSTITUTE
    7        2   NATIONAL EYE INSTITUTE
    8        2   NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN D
    9        1   NATIONAL HUMAN GENOME RESEARCH INSTITUTE
   10        1   NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKE
   11        1   NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RE
   12        1   NATIONAL INSTITUTE OF MENTAL HEALTH
   13        1   NATIONAL INSTITUTE ON AGING
   14        1   NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHO
   15        1   NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMU          
---end of results---

P =  next page      Pn = Jump to page n
P- = previous page  M =  More Options     Exit = Leave RANK

To view records from RANK, enter VIEW followed by RANK number,
format, and item(s) to display, e.g., VIEW 2/9/ALL.

Enter desired option(s) or enter RANK number(s) to save terms.
?exit 

RANK results will be erased; have you saved all the terms of 
interest? (YES/NO)
?y

Exiting...  (no terms were saved)

6. TYPE selected record(s) in Format 9 for the full record.

Records provide contact information of the principal investigator.

Fields available to search project dates include Starting Date (SD=) and Completion Date (CD=).

Note: Part of this record is omitted from the display.

?t s2/9/1

2/9/1 
  DIALOG(R)File 266: FEDRIP
  Comp & dist by NTIS, Intl Copyright All Rights Res. 
All rights reserved.
  
  00655026 
  Identifying No.: 5R01MH066877-07   Agency Code: CRISP 
  Searching for ADHD Susceptibility Genes 
  
  Principal Investigator: FARAONE, STEPHEN V, PHD 
  Address: FARAONES@UPSTATE.EDU SUNY UPSTATE MEDICAL UNIVERSITY 
750 E ADAMS STREET SYRACUSE, NY 13210 
  Performing Org.: UPSTATE MEDICAL UNIVERSITY, SYRACUSE, NEW YORK 
  Sponsoring Org.: NATIONAL INSTITUTE OF MENTAL HEALTH 
  Dates: 2006/01/02 To 2003/31/11   Fy : 2008  
  Type Of Award: Noncompeting Continuation (Type 5) 

 Summary: DESCRIPTION (provided by applicant): Attention Deficit 
Hyperactivity Disorder (ADHD) is a common disorder of childhood 
associated with school failure, psychiatric co-morbidity and 
psychosocial disability. Family and twin studies suggest that 
ADHD has a substantial genetic component and, unlike other 
psychiatric conditions that have produced an array of conflicting 
results, molecular genetic research into ADHD has produced a body 
of work implicating several genes in the etiology of the disorder. 
In the first funding cycle of this grant, we have used a family- 
based association study to search for variants that result in 
increased susceptibility to ADHD for the DRD4, SLC6A3, DRD5, 
SNAP25 and HTR1B genes. That work has found evidence for haplotypes 
of the HTR1B and SNAP25 genes as increasing susceptibility to ADHD. 
We have resequenced the risk haplotypes in 48 ADHD affecteds, 
resequencing a total of 115kb identifying a total of 350 SNPs of 
which 200 are novel. In this proposed renewal, we plan to confirm 
and extend the haplotype association results for HTR1B, SLC6A3 
and SNAP25 using family-based and case-control samples. 
Identifying true causal variants after observing haplotypic 
associations presents a challenge because the SNPs sampled in a 
given haplotype block are correlated and may not include the 
causal polymorphisms of interest.
. . . .
Descriptors: attention  deficit disorder; pathologic process; 
gene interaction; genotype;  nucleic acid sequence; longitudinal 
human study; phenotype ; family  genetics; human data; gene 
environment interaction; clinical research; disease/disorder 
etiology; genetic susceptibility; single nucleotide polymorphism