1. BEGIN File 55 to search BIOSIS Previews, which includes data from 1993 to the present.

Note: File 5 contains data from 1926 to the present.

2. SELECT terms word-by-word with proximity connectors (W) and qualify to the Title OR the Descriptor (/TI,DE) fields. Be sure to OR in synonyms or acronyms and “nest” the terms in parentheses so that Dialog restricts all the terms to the two fields.

?b 55

File  55:Biosis Previews(R) 1993-2008/Jul W3
       (c) 2008 The Thomson Corporation

      Set  Items  Description
      ---  -----  -----------
?s (vascular(w)endothelial(w)growth(w)factor? or vegf)/ti,de

         1313168  VASCULAR/TI,DE
          114452  ENDOTHELIAL/TI,DE
          463777  GROWTH/TI,DE
          671111  FACTOR?/TI,DE
           26957  VASCULAR/TI,DE(W)ENDOTHELIAL/TI,DE
                  (W)GROWTH/TI,DE(W)FACTOR?/TI,DE
           18477  VEGF/TI,DE
      S1   29724  (VASCULAR(W)ENDOTHELIAL(W)GROWTH(W)FACTOR?
                  OR VEGF)/TI,DE

3. EXPAND a word to enter the thesaurus and see if it has related terms. The third column, RT, appears. It indicates that “animals” has two related terms.

4. EXPAND E3 to view related terms for animals.

Note: you can bypass the initial expand by entering the thesaurus term in parentheses (e.g., EXPAND animals).

5. Animals has a broader term, “Taxa Notes Terms,” with 73 related terms. Taxa Notes are controlled common names of broad groups of organisms.

EXPAND R2 to view these related terms from which you can choose the appropriate R reference number.

The benefits of using controlled vocabulary include improved relevancy and precision.

Note: Portions of the Expand display are omitted from the display.

6. SELECT the appropriate “R” number(s).

?e animals

Ref   Items   RT  Index-term
E1        2       ANIMALPLAN
E2        1       ANIMALQTLDB
E3  6773223    2 *ANIMALS
E4     3687       ANIMALS (ANIMALIA)
E5        7       ANIMALS (SCIENTIFIC PROCEDURES) ACT 1986
E6        1       ANIMALS ACT 1986
E7        1       ANIMALS BITEMARKS
E8        1       ANIMALS CARCINOGENICITY MUTAGENS EXTRAHEPATIC
E9        1       ANIMALS CELLS
E10       1       ANIMALS COMMUNICATION
E11       1       ANIMALS COMPARATIVE ANATOMY CLASSIFICATION MOL
E12       1       ANIMALS FEED

?e e3

Ref   Items Type  RT  Index-term
R1  6773223        2 *ANIMALS
R2        0   B   73  TAXA NOTES TERMS
R3  6760478   R    4  ANIMALIA

Enter P or PAGE for more

?e r2

Ref   Items Type  RT  Index-term
R1        0       73 *TAXA NOTES TERMS
R2        0   B    4  TAXA NOTES
R3    74015   N   11  ALGAE
R4    68876   N    2  AMPHIBIANS
R5   729624   N    2  ANGIOSPERMS
R6  6773223   N    2  ANIMALS
R7    16584   N    2  ANNELIDS
R8    13550   N    8  ARCHAEOBACTERIA
R9   386126   N    2  ARTHROPODS
R10  304683   N    2  ARTIODACTYLS
R11   58084   N    2  ASCHELMINTHS
R12  700379   N    5  BACTERIA
R13   10515   N    2  BATS
R14  174983   N    2  BIRDS
R15   12301   N    2  BRYOPHYTES
R16  140118   N    2  CARNIVORES
R17    8166   N    2  CETACEANS
R18   39549   N    2  CHELICERATES
. . .
R48   37663   N    2  NEGATIVE SENSE SINGLE-STRANDED RNA VIRUSES
R49 2109595   N    1  NONHUMAN MAMMALS
R50  104906   N    1  NONHUMAN PRIMATES

Enter P or PAGE for more

?s r49
      S2 2109595  'NONHUMAN MAMMALS'

7. Combine Search Sets 1 and 2 (S1 and S2).

8. Use database LIMIT options to restrict retrieval to the most recent publication year.

?s s1 and s2

           29724  S1
         2109595  S2
      S3   12695  S1 AND S2

?s s3/2008

           12695  S3
          195062  PY=2008
      S4     507  S3/2008

9. TYPE a few records in Format 8 to view titles, descriptors and publication years.

Browse through the Descriptor terms and take in the specific subfields. This method provides additional insight to tailor a search to a specific concentration.

Notice the Major Concepts field. Major Concepts are not designed to stand alone, but to be used in conjunction with other descriptors for a more focused search.

Nonhuman Mammals picked up a variety of sub-terms in the hierarchy.

To select the appropriate record number, look at the range of records in the Type command (e.g., 4/8/2).

Note: Some records are omitted from the display and portions of the records are not shown.

?t s4/8/1-5

4/8/1
DIALOG(R)File 55: Biosis Previews(R)
(c) 2008 The Thomson Corporation. All rights reserved.

0020360934   Biosis No.: 200800407873
TNF receptor I sensitizes neurons to erythropoietin- and VEGF -mediated neuroprotection after ischemic and excitotoxic injury

2008
Registry Numbers: 61912-98-9: insulin-like growth factor; 9061-61-4: nerve growth factor; 487-79-6: kainic acid; 127464-60-2: VEGF; 11096-26-7: erythropoietin
DESCRIPTORS:
Major Concepts: Molecular Genetics--Biochemistry and Molecular Biophysics; Nervous System-- Neural Coordination
Biosystematic Names: Muridae--Rodentia, Mammalia, Vertebrata, Chordata, Animalia
Organisms: mouse (Muridae)--male
Organisms: Parts Etc: neuron--nervous system; primary cortical neurons--nervous system
Common Taxonomic Terms: Animals; Chordates; Mammals; Nonhuman Vertebrates; Nonhuman Mammals; Rodents; Vertebrates
Diseases: ischemic injury--vascular disease; seizure--nervous system disease; excitotoxic injury--nervous system disease
Mesh Terms: Ischemia (MeSH); Seizures (MeSH)
 Chemicals & Biochemicals:   Bcl-2; neurotransmitter; insulin-like growth factor {IGF}; nerve growth factor {NGF}; kainic acid; differentiation factors; VEGF--expression ; TNF receptor-1; EPO receptor--expression; erythropoietin--neuroprotective cytokine; colony-stimulating factor receptor-1
Gene Name: mouse TNFR1 gene (Muridae) {mouse TNF receptor 1 gene}--expression
Methods & Equipment: cerebral artery occlusion--therapeutic and prophylactic techniques, clinical techniques
 Miscellaneous Terms: Concept Codes: cell cycle; neuroprotection; glucose deprivation; oxygen-glucose deprivation; DNA repair machinery
Concept Codes:
02506 Cytology - Animal
 03502 Genetics - General
  03506 Genetics - Animal
 . . .
  20506 Nervous system - Pathology
Biosystematic Codes:
86375 Muridae

10. TYPE selected records in Format 7, which gives the bibliographic citation and the abstract.

Searchers who have enabled their User IDs for Dialog eLinks can click on the publisher’s icon to get the fulltext document.

BIOSIS provides a Digital Object Identifier, (DOI) “Item Identifier,” which may take you directly to the fulltext of the document or to a professional society website that restricts display to members only, or to the publisher’s website, where you may purchase the fulltext.

?t s4/7/1
Dialog eLink:
4/7/1
DIALOG(R)File 55: Biosis Previews(R)
(c) 2008 The Thomson Corporation. All rights reserved.

0020360934   Biosis No.: 200800407873
TNF receptor I sensitizes neurons to erythropoietin- and VEGF -mediated neuroprotection after ischemic and excitotoxic injury

Author: Taoufik Era; Petit Edwige; Divoux Didier; Tseveleki Vivian; Mengozzi Manuela; Roberts Michael L; Valable Samuel; Ghezzi Pietro; Quackenbush John ; Brines Michael; Cerami Anthony; Probert Lesley (Reprint)
Author Address: Hellen Pastuer Inst, Lab Mol Genet, Athens 11521, Greece**Greece
Author E-mail Address: acerami@warrenpharma.com; lesley.probert@pasteur.gr
Journal: Proceedings of the National Academy of Sciences of the United States of America   105 ( 16 ): p 6185-6190 APR 22 2008 2008
Item Identifier: doi:10.1073/pnas.0801447105
ISSN: 0027-8424
Document Type: Article
Record Type: Abstract
Language: English

Abstract: CNS neurons use robust cytoprotective mechanisms to ensure survival and functioning under conditions of injury. These involve pathways induced by endogenous neuroprotective cytokines such as erythropoietin (EPO). Recently, in contrast to its well known deleterious roles, TNF has also been shown to exhibit neuroprotective properties. In the present study, we investigated the molecular mechanisms by which TNF receptor (TNFR)I mediates neuroprotection by comparing the gene expression profiles of lesioned cortex from WT and TNFRI KO mice after permanent middle cerebral artery occlusion. Several known neuroprotective molecules were identified as TNFRI targets, notably members of the Bcl-2 family, DNA repair machinery and cell cycle, developmental, and differentiation factors, neurotransmitters and growth factors, as well as their receptors, including EPO receptor (EPOR), VEGF, colony-stimulating factor receptor 1, insulin-like growth factor (IGF), and nerve growth factor (NGF). Further analysis showed that induction of EPOR and VEGF expression in primary cortical neurons after glucose deprivation (GD) largely depended on TNFRI and was further up-regulated by TNF. Also, EPO- and VEGF-induced neuroprotection against GD, oxygen-glucose deprivation, and NMDA excitotoxicity depended significantly on TNFRI presence. Finally, EPO prevented neuronal damage induced by kainic acid in WT but not TNFRI KO mice. Our results identify cross-talk between tissue protective cytokines, specifically that TNFRI is necessary for constitutive and GD-induced expression of EFOR and VEGF and for EIPO-mediated neuroprotection.