1. BEGIN File 154 to search MEDLINE.

2. SELECT a descriptor term restricting to /MAJ and Link (L) to desired allowable subheadings.

This example shows oxycodone linked to adverse effects, toxicity, poisoning or contraindications.

3. SELECT Set 1 (S1) restricting results to English language articles and human subjects.

?b 154 
 
       File 154:MEDLINE(R) 1990-2007/Mar 15
       (c) format only 2007 Dialog

      Set  Items  Description
      ---  -----  -----------
?s oxycodone/maj (L)  (ae or to or po or ct)
             334  OXYCODONE/MAJ
          588348  AE/DE
          224688  TO/DE
           20007  PO/DE
           11452  CT/DE
      S1      55  OXYCODONE/MAJ (L) (AE OR TO OR PO OR CT)

?s s1/eng,human
      S2      53  S1/ENG,HUMAN

4. TYPE a few records in Format 8 to see titles, descriptors and publication years.

To select the appropriate record number, look at the range of records in the TYPE command (e.g., 1/8/1-3).

?t  s2/8/1-3

  2/8/1 
  DIALOG(R)File 154: MEDLINE(R)
  (c) format only 2007 Dialog. All rights reserved.
  
  21800529   PMID: 16987359 
  Assessing cognition and psychomotor function under long-term 
treatment with  controlled release oxycodone in non-cancer 
pain patients. 
  
  Jul 2006 
  Tags: Female; Male 
  Descriptors: *Analgesics, Opioid--adverse effects--AE; 
*Cognition--drug  effects--DE; *Oxycodone--adverse effects--AE; 
*Psychomotor Performance--drug  effects--DE ; Adult; Aged; 
Aging--physiology--PH; Analgesics,  Opioid--administration and 
dosage--AD; Analgesics, Opioid--therapeutic use--TU;  
Arousal--drug effects --DE; Attention--drug effects--DE; 
Automobile Driving;  Delayed-Action Preparations; Endpoint 
Determination; Germany; Humans; Middle  Aged; Oxycodone--
administration and dosage--AD; Oxycodone--therapeutic use--TU 
  CAS Registry No.: 0 (Analgesics, Opioid); 0 (Delayed-Action  
Preparations); 76-42-6 (Oxycodone) 
  
  2/8/2 
  DIALOG(R)File 154: MEDLINE(R)
  (c) format only 2007 Dialog. All rights reserved.
  
  21692807   PMID: 16669750 
  Medication sleuth: an important role for pharmacists in 
determining the  etiology of delirium. 
  
  Apr 2006 
  Tags: Female 
  Descriptors: *Delirium--chemically induced--CI; 
*Narcotics--adverse  effects--AE; >*Oxycodone--adverse 
effects--AE; *Pharmacists; *Substance  Withdrawal Syndrome ; 
Aged; Delirium--drug therapy--DT; Diagnosis,  Differential; 
Hospitalization; Humans; Hypnotics and 
Sedatives--poisoning--PO;  Medical History Taking; 
Overdose--therapy--TH; Patient Care Team;  
Pyridines--pharmacology--PD; Pyridines--poisoning--PO; 
Substance Withdrawal  Syndrome--diagnosis--DI 
  CAS Registry No.: 0 (Hypnotics and Sedatives); 0 
(Narcotics); 0  (Pyridines); 76-42-6 (Oxycodone); 
82626-48-0 (zolpidem) 


  2/8/3 DIALOG(R)File 154: MEDLINE(R)
  (c) format only 2007 Dialog. All rights   reserved.
      
  15920572   PMID: 16368927 
  Serotonin   syndrome induced by fluvoxamine and oxycodone. 
      
  Jan 2006 
  Tags: Female 
  Descriptors: *Fluvoxamine--adverse effects--AE;   
*Oxycodone--adverse effects-- AE; *Serotonin 
Syndrome--chemically   induced--CI ; Aged; Analgesics, 
Opioid--adverse effects--AE; Analgesics,   Opioid 
--therapeutic use--TU; Depression--drug therapy--DT; Drug 
Interactions;   Fluvoxamine--therapeutic use--TU; Humans; 
Oxycodone--therapeutic use--TU;   Pain--drug therapy--DT; 
Serotonin Syndrome--physiopathology--PP; Serotonin   Uptake 
Inhibitors--adverse effects--AE; Serotonin Uptake Inhibitors
--therapeutic use--TU 
  CAS Registry No.: 0 (Analgesics, Opioid); 0   (Serotonin 
Uptake Inhibitors); 54739-18-3 (Fluvoxamine); 76-42-6 
(Oxycodone) 

5. TYPE a record(s) you wish to view using Format 7 for the title, bibliographic citation and abstract.

The citation chosen is record 3.

?t  s2/7/3 

  2/7/3 
  DIALOG(R)File 154: MEDLINE(R)
  (c) format only 2007 Dialog. All rights   reserved.

  15920572   PMID: 16368927 
  Serotonin   syndrome induced by fluvoxamine and oxycodone. 
      
      Karunatilake Harindra; Buckley Nicholas A 
      The Canberra Hospital, Canberra, New South Wales, 
Australia. 
      Annals of pharmacotherapy ( United States )     
Jan 2006 ,   40 (1) p155-7   ,  ISSN: 1060-0280--Print   
Journal Code: 9203131 
      Publishing Model Print-Electronic 
      Document type: Case Reports; Journal Article 
      Languages: ENGLISH 
      Main Citation Owner: NLM 
      Record type: MEDLINE;   Completed 
      OBJECTIVE: To report a case of severe serotonergic symptoms
following the addition of oxycodone to fluvoxamine. CASE SUMMARY: 
A 70-year-old   woman developed severe serotonergic features, 
including confusion, nausea,   fever, clonus, hyperreflexia, 
hypertonia, shivering, and tachycardia, following   the addition 
of oxycodone 40 mg twice daily to fluvoxamine 200 mg/day, easily
fulfilling diagnostic criteria for serotonin syndrome. 
Discontinuation of the   offending drugs resulted in resolution 
of her symptoms over 48 hours, and no   other cause of the 
syndrome was identified. Use of the Naranjo probability scale
indicated a probable relationship between the serotonergic 
symptoms and the   addition of oxycodone to fluvoxamine therapy. 
DISCUSSION: Serotonin syndrome is   a serious adverse reaction 
usually due to interactions with serotonergic drugs.   There 
have been only 3 previous reports involving oxycodone. Most 
previous   reports of serotonin syndrome involving analgesics 
have been associated with   meperidine, dextromethorphan, and 
tramadol. Unlike these synthetic opioids,   however, oxycodone 
does not inhibit the reuptake of serotonin. In addition,   
there are a number of other possible pharmacologic mechanisms 
for the   interaction we observed. CONCLUSIONS: Monitoring for 
serotonergic adverse events   should be done when oxycodone is 
given to patients receiving serotonin-reuptake   inhibitors. 
      Record Date Created: 20060106 
      Record Date   Completed: 20060410 
      Date of Electronic Publication: 20051220