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Search for a Biomedical Subject?
TOPIC: When it comes to finding comprehensive and timely answers to important health issues quickly, medical researchers turn to Dialog. Dialog offers a broad spectrum of databases of importance to researchers in the areas of life sciences, chemistry, pharmacology and others.
Four databases on Dialog have the broadest coverage of biomedical literature: MEDLINE® (File 154), EMBASE® (File72), BIOSIS Previews® (File 55), and SciSearch®--A Cited Reference Database (File 34). This gives you the advantage of using more than one database to access thousands of sources. Each file has its strengths, its focus and its unique journals. A look at titles after removing duplicates reveals the importance and the ease of searching several files at once on Dialog.
Recent news articles suggest that antibiotics can be used to treat neurological diseases such as Lou Gehrig’s Disease (ALS).
In this example, you will find recent articles in the biomedical literature on using antibiotics to treat amyotrophic lateral sclerosis (Lou Gehrig’s Disease or ALS). You will search the four core biomedical databases, remove duplicates and view titles from each of the databases.
COMMAND SUMMARY
BEGIN 154,72,55,34 CURRENT
SELECT AMYOTROPHIC(W)LATERAL(W)SCLEROSIS
SELECT TREATMENT OR CURE? OR THERAP?
SELECT ANTIBIOTIC?
SELECT S1 AND S2 AND S3
SELECT S4/2006:2007
RD
TYPE S6/8/1-3 FROM EACH
TYPE S6/7/3 FROM 72
HOW TO...

1. BEGIN Files 154,72,55,34 to search the four key biomedical databases together. Use the CURRENT feature to restrict the search to this year plus one year back.
2. SELECT terms for the first concept. Use the proximity connector (W) for words adjacent to each other in exact order. OR the synonyms together.
3. SELECT the second concept using OR for synonyms.
4. SELECT the third concept.
5. Combine the three sets using the AND operator.
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?b 154,72,55,34 current
SYSTEM:OS - DIALOG OneSearch
File 154:MEDLINE(R) 1990-2007/Mar 15
(c) format only 2007 Dialog
File 72:EMBASE 1993-2007/Mar 20
(c) 2007 Elsevier B.V.
File 55:Biosis Previews(R) 1993-2007/Mar W2
(c) 2007 The Thomson Corporation
File 34:SciSearch(R) Cited Ref Sci 1990-2007/Mar W2
(c) 2007 The Thomson Corp
>>>CURRENT is not available in file(s): >>> 154
>>>The full file(s) will be searched.
>>>CURRENT started
Set Items Description
--- ----- -----------
?s amyotrophic(w)lateral(w)sclerosis or als
10251 AMYOTROPHIC
127662 LATERAL
63401 SCLEROSIS
10166 AMYOTROPHIC(W)LATERAL(W)SCLEROSIS
14990 ALS
S1 19512 AMYOTROPHIC(W)LATERAL(W)SCLEROSIS OR ALS
?s treatment or cure? or therap?
1846901 TREATMENT
60785 CURE?
2291429 THERAP?
S2 3151738 TREATMENT OR CURE? OR THERAP?
?s antibiotic?
S3 156005 ANTIBIOTIC?
?s s1 and s2 and s3
19512 S1
3151738 S2
148321 S3
S4 205 S1 AND S2 AND S3 |

6. Narrow the search to a specific range of publication years.
7. REMOVE DUPLICATES (RD) when searching more than one database.
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?s s4/2006:2007
205 S4
3413000 PY=2006 : PY=2007
S5 55 S4/2006:2007
?rd
S6 43 RD (unique items) |

8. TYPE a few records from each of the databases in Format 8 to see title, descriptors and publication years.
Add FROM EACH to the end of the TYPE command to see one or more records from each database in the search.
To select the appropriate record number, look at the range of records in the TYPE command (e.g., 6/8/2).
Note: Some records have been omitted from this display. |
?t s6/8/1-3 from each
6/8/1 (Item 1 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2007 Dialog. All rights reserved.
22954626 PMID: 17326477
[Osteonecrosis of the jawbone as a side effect of intravenous
treatment with bisphosphonates]
Osteonecrose van het kaakbot als bijwerking van de intraveneuze
behandeling met bisfosfonaten.
Feb 3 2007
6/8/2 (Item 2 from file: 154)
DIALOG(R)File 154: MEDLINE(R)
(c) format only 2007 Dialog. All rights reserved.
22835334 PMID: 17212618
Motor neuron disease recovery associated with IV ceftriaxone and
anti-Babesia therapy.
Feb 2007
. . .
6/8/13 (Item 1 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2007 Elsevier B.V. All rights reserved.
14193368 EMBASE No: 2006281822
Comment by Dr. Jeffrey D. Rothstein
Publication Date: 2006
DRUG DESCRIPTORS:
* ceftriaxone--clinical trial--ct; *ceftriaxone--drug therapy--
dt;* ceftriaxone--pharmacology--pd
beta lactam antibiotic--clinical trial--ct; beta lactam
antibiotic--drug therapy--dt; beta lactam antibiotic--
pharmacology--pd
MEDICAL DESCRIPTORS:
* amyotrophic lateral sclerosis--drug therapy--dt
drug mechanism; gene expression; molecular mechanics;
transcription regulation; concentration response; drug
research; drug approval; drug efficacy; human; nonhuman;
clinical trial; note; priority journal
CAS Registry Number: 73384-59-5, 74578-69-1 (ceftriaxone)
6/8/14 (Item 2 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2007 Elsevier B.V. All rights reserved.
14193367 EMBASE No: 2006281821
New ideas for therapy in ALS: Critical considerations
Publication Date: 2006
DRUG DESCRIPTORS:
* ceftriaxone--clinical trial--ct; *ceftriaxone--drug therapy--
dt; * ceftriaxone--pharmacology--pd
beta lactam antibiotic--clinical trial--ct; beta lactam
antibiotic--drug therapy--dt; beta lactam antibiotic--
pharmacology--pd; glutamate transporter--endogenous
compound--ec; superoxide dismutase--endogenous compound--ec
MEDICAL DESCRIPTORS:
* amyotrophic lateral sclerosis--drug therapy--dt
high throughput screening; drug approval; drug mechanism;
drug efficacy; drug safety; gene expression; muscle strength;
drug response; statistical analysis; statistical significance;
neuroprotection; human; nonhuman; clinical trial; letter;
priority journal
CAS Registry Number: 73384-59-5, 74578-69-1 (ceftriaxone);
37294-21-6, 9016-01-7, 9054-89-1 ( superoxide dismutase)
6/8/15 (Item 3 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2007 Elsevier B.V. All rights reserved.
14193266 EMBASE No: 2006140699
Management of respiration in MND/ALS patients: An evidence
based review
Publication Date: 2006
DRUG DESCRIPTORS:
benzodiazepine derivative--drug therapy--dt; narcotic
analgesic agent--drug therapy--dt; antibiotic agent--drug
therapy--dt; oxygen--drug therapy--dt
MEDICAL DESCRIPTORS:
* motor neuron disease; *amyotrophic lateral sclerosis;
*respiratory failure --complication--co; *respiratory
failure--diagnosis--di; *respiratory failure--disease
management--dm; *respiratory failure--drug therapy--dt;
* respiratory failure--therapy--th evidence based medicine;
systematic review; information processing; practice
guideline; qualitative analysis; non invasive procedure;
assisted ventilation; diagnostic value; artificial
ventilation; diaphragm paralysis; spirometry; forced
expiratory volume; sleep disorder; hypoventilation; health
care cost; electromyography; palliative therapy; adjuvant
therapy; oxygen therapy; tracheostomy; quality of life;
intermittent positive pressure ventilation; treatment
withdrawal; human; clinical trial; meta analysis; review;
priority journal
CAS Registry Number: 7782-44-7 (oxygen)
6/8/40 (Item 1 from file: 34)
DIALOG(R)File 34: SciSearch(R) Cited Ref Sci
(c) 2007 The Thomson Corp. All rights reserved.
15321945 Genuine Article#: 058WX Number of References: 190
Mechanisms of the antinociceptive action of gabapentin
( ABSTRACT AVAILABLE )
Publication date: 20060000
Journal Subject Category: PHARMACOLOGY & PHARMACY
Descriptors--Author Keywords: gabapentin ; GABA(B) receptor
; NMDA receptor ; K-ATP channel ; alpha(2)delta subunit of
Ca2+ channels
Identifiers-- KeyWord Plus(R): CALCIUM-CHANNEL BLOCKERS;
GAMMA-AMINOBUTYRIC-ACID; RAT SPINAL-CORD; RANDOMIZED
CONTROLLED-TRIAL; NEUROPATHIC PAIN MODEL; ADMINISTERED
AMINOGLYCOSIDE ANTIBIOTICS; AMYOTROPHIC-LATERAL-SCLEROSIS;
CAUDAL TRIGEMINAL NUCLEUS; ROOT GANGLION NEURONS; SUBUNIT
UP-REGULATION
6/8/41 (Item 2 from file: 34)
DIALOG(R)File 34: SciSearch(R) Cited Ref Sci
(c) 2007 The Thomson Corp. All rights reserved.
15207943 Genuine Article#: 047US Number of References: 27
Predictors of severe chest infections in pediatric
neuromuscular disorders
( ABSTRACT AVAILABLE )
Publication date: 20060500
Journal Subject Category: CLINICAL NEUROLOGY; NEUROSCIENCES
Descriptors--Author Keywords: spirometry ; respiratory muscle
function ; peak cough flow ; severe chest infection
Identifiers-- KeyWord Plus(R): AMYOTROPHIC-LATERAL-SCLEROSIS;
MECHANICAL INSUFFLATION-EXSUFFLATION; MUSCULAR-ATROPHY TYPE-1;
RESPIRATORY-FAILURE; DISEASE; COUGH; CLEARANCE; WEAKNESS;
HOSPITALIZATION; ATELECTASIS
. . . |

9. TYPE selected records in Format 7, which gives you the Bibliographic Citation and the Abstract.
Use the FROM command and the database number to select a record from a particular database.
Note: Part of this record is omitted from the display.
|

?t s6/7/3 from 72
6/7/15 (Item 3 from file: 72)
DIALOG(R)File 72: EMBASE
(c) 2007 Elsevier B.V. All rights reserved.
14193266 EMBASE No: 2006140699
Management of respiration in MND/ALS patients: An evidence
based review
Heffernan C.; Jenkinson C.; Holmes T.; Macleod H.; Kinnear W.;
Oliver D.; Leigh N.; Ampong M.-A.
C. Jenkinson, Department of Public Health, Old Road Campus,
Headington, Oxford OX3 7LF United Kingdom
Author Email: crispin.jenkinson@hmc.ox.ac.uk
Amyotrophic Lateral Sclerosis ( AMYOTROPHIC LATERAL SCLER. )
( United Kingdom ) 2006 , 7/1 (5-15)
CODEN: ALSCF ISSN: 1748-2968 eISSN: 1471-180X
Publisher Item Identifier: H886128306313847
Document Type: Journal ; Review
Language: ENGLISH Summary Language: ENGLISH
Number Of References: 86
This systematic review comprises an objective appraisal of
the evidence in regard to the management of respiration in
patients with motor neuron disease (MND/ALS). Studies were
identified through computerised searches of 32 databases.
Internet searches of websites of drug companies and MND/ ALS
research web sites, 'snow balling' and hand searches were
also employed to locate any unpublished study or other
'grey literature' on respiration and MND/ALS. Since
management of MND/ALS involves a number of health
professionals and care workers, searches were made across
multiple disciplines. No time frame was imposed on the
search in order to increase the probability of identifying
all relevant studies, although there was a final limit of
March 2005. Recommendations for patient and carer-based
guidelines for the clinical management of respiration
for MND/ALS patients are suggested
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